Will ‘green’ aspects of dried blood spot sampling accelerate its implementation and acceptance in the pharmaceutical industry?
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"The broader application of DBS in pharmacokinetic analysis is an excellent example of a ‘green’ technique based on the benefits in reduction of animals, chemicals, labware and energy consumption." Green chemistry is a philosophy of chemical research and engineering that encourages the design of products and processes minimizing the use and generation of hazardous substances [101]. Dried blood spot (DBS) technology has existed for over 40 years [1], but has recently gained attention as a microsampling technology for nonclinical and clinical pharmacokinetic analysis [2,3]. Method development and validation, and subsequent sample analysis, have been successfully carried out using LC–MS/MS and...
