What is the potential of dried matrix spot sampling for cerebrospinal fluid analysis?

The DBS method of blood sampling on paper, a major innovation introduced in the early 20th century, provided a valuable alternative to classical blood sampling methods [1]. It took almost 60 years before this alternative was used in clinical settings for the systematic neonatal screening of the metabolic disease phenylketonuria [2]. The fact that DBS methods lend themselves to testing fragile patients such as newborn infants makes them particularly useful in the field of clinical biology. However, more than 100 years after their development, they are not being used in routine clinical practice although many analytes such as proteins, nucleic...