What is needed for optimal therapeutic drug monitoring?

“In order for therapeutic drug monitoring to be most effective, there must be harmonization of methods and more rigorous determination of therapeutic intervals.” Therapeutic drug monitoring (TDM) can be defined as the practical application of PK in drug management – measurement of the blood concentration of a drug relative to its administration for the purpose of adjusting the dosage as necessary. In the current era of personalized medicine, much of the focus is on the relevance of genetic testing in directing drug management. However, one could argue that personalized medicine has been performed in practice for the past 40 years,...