What are the advantages of RP-HPLC methods for the detection of drugs in plasma?

"Specific clinical applications have resulted in not only necessity for high-speed, efficient and selective chromatographic systems, but also simplified sample processing, which determines the effectiveness of the overall bioanalytical assay." In routine clinical laboratories, determination of drugs in plasma is a multistep procedure including sample pretreatment, calibration, chromatographic separation and detection, most often by MS. Nowadays, there has been a growing interest in automation of the whole procedure, offering significant savings in operation time. This has lead to automation in sample processing and online tandem chromatographic techniques, such as multidimensional development or ultra performance convergence chromatography (UPC2) providing orthogonal and...