The origin-adjusted approach for biomarker quantification by LC–MS
Wednesday 13 November 2024
07:00 [PST] 10:00 [EST] 15:00 [GMT]
Alternative time zones
A foray into the dynamics and usefulness of the origin-adjusted approach and why it should be a prominent choice for biomarker quantification.
This webinar explores the great potential utility of the origin-adjusted approach for the determination of biomarkers in biological matrices by LC–MS. An approach based on standard addition, it features all the benefits of the proven, long-established and much-loved technique. Furthermore, it clarifies and extends the principle, showing how elegantly the endogenous level can be numerically removed based on the dynamics of the linear regression and the placement of the line on the origin. This results in a prominent quantitative option advantageous in its affordability, rapidity and reliability within a high-throughput interpolative workflow, with no need to demonstrate parallelism.
What will you learn?
- Background to biomarker quantification and the established approaches
- Standard addition as the essence of an approach
- The level-up of standard addition to origin-adjustment
- Features and advantages of the origin-adjusted approach
Who this may interest?
- Bioanalytical scientists
- Biomarker-focused scientists
- Regulators
Speaker
Robert MacNeill
Director of Bioanalysis
Pharmaron (PA, USA)
Robert is a Director of Bioanalysis at Pharmaron in Exton, and has a background dominated by quantitative bioanalytical LC–MS, particularly method development, leaning toward novel techniques and approaches. The regulated bioanalytical area within the contract research domain is where Robert has applied his skills for decades.
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