New UPC²® Separation Technology: SFC/MS/MS for Applications Within DMPK

This presentation is the 1st in the series of 3 webinars brought to you by Waters Corporation and Bioanalysis Zone on “Scientists Helping Scientists Meet New Challenges in Pharmaceutical Drug Discovery and Development”.

In this webinar Chet Bowen of GlaxoSmithKline and Jennifer L. Simeone of Waters Corporation will discuss “New UPC²® Separation Technology: SFC/MS/MS for Applications Within DMPK”.

Topics Covered:

  • Understand how UltraPerformance Convergence Chromatography™ (UPC²®) can help in the DMPK environment
  • Learn the advantages of supercritical CO2 as the major mobile phase when compared to traditional reversed phase or normal phase liquid chromatography
  • Learn more about the growing interest/requirement in chiral metabolite identification and quantification during drug development

Panelist Biographies:

Chet Bowen
Investigator and Team Leader
GlaxoSmithKline Pharmaceuticals
Bioanalytical Science and Toxicokinetics PTS DMPK

Chet Bowen is an Investigator and Team Leader within Bioanalytical Science and Toxicokinetics at GlaxoSmithKline Pharmaceuticals in King of Prussia, PA.  He has worked in bioanalysis, method development and laboratory management for over 18 years in the pharmaceutical, contract research, government, clinical, and environmental industries.

Chet has a B.S. in Biology and a M.S. in Biochemistry, both from the University of Scranton, in Pennsylvania.  Past positions include: environmental chemist at the Armed Forces Institute of Pathology, performing research on Gulf War Illness; laboratory manager at Johns Hopkins University, researching ways to minimize childhood lead poisoning in urban environments; and project manager at Bioanalytical Systems, managing a team of scientists performing method development and validation.

Current research interests include application of micro-sampling (blood and plasma) techniques to the analysis of zenobiotics.  He is actively developing analytical methods for both biomarkers and biopharmaceutical utilizing LC-MS/MS.  Currently he is also researching the stability of glucuronides in both dried plasma and dried blood spots.  He has published numerous papers and presented data on method development, validation and dried blood spot methods.

Jennifer L. Simeone
Senior Chemist
Waters Corporation
Jennifer Simeone is a Senior Chemist in the Early Stage Development Group within Pharmaceutical and Life Sciences at Waters Corporation in Milford, MA. She earned an M.S. in Chemistry from the University of Massachusetts in 2005.  Her main focus is on the development and evaluation of novel technologies and processes within bioanalytical applications, specifically relating to LC/MS/MS.  Prior to joining Waters in 2010, she worked for Charles River Laboratories, within the Bioanalytical Chemistry department.