Driving more sensitive and selective bioanalysis using accurate mass spectrometry
Quantitation of small and large molecule therapeutics in biological matrices is important during drug development. Quadrupole-based liquid chromatography coupled with mass spectrometry (LC-MS) has been routinely adopted for the quantitation of therapeutics in bioanalytical laboratories. Advances in accurate mass spectrometry have enabled it to become a complementary option for quantitative bioanalysis. These advances include greater selectivity, improved mass resolution and the flexibility of time-of-flight (TOF) MS/MS for data analysis.
These advances include greater selectivity, improved mass resolution and the flexibility of time-of-flight (TOF) MS/MS for data analysis. Here, quantitative analysis was performed on the ZenoTOF 7600 system, where the application of the Zeno trap enhanced overall MS/MS sampling efficiency and boosted quantitative sensitivity for bioanalysis.
What will you learn?
- How to achieve low-level quantitation of small and large molecules in challenging biological matrices using the ZenoTOF 7600 system, featuring the Zeno trap for enhanced MS/MS sampling efficiency
- How to streamline quantitation methods by collecting data over a wide MS/MS range for flexible post-acquisition data processing
- How to increase productivity with a user-friendly interface and integrated platform for data acquisition, processing and management for routine bioanalysis using SCIEX OS software
Who may this interest?
- Researchers in drug discovery and development
- Drug developers performing pharmacokinetic studies and regulated bioanalysis
Speaker
Eshani Nandita, PhD
Global Technical Marketing Lead
SCIEX (MA, USA)
Eshani holds a doctorate degree in analytical chemistry from the University of California, Davis (CA, USA), where she developed mass spectrometry-based methods to study carbohydrate structures and functions in gut health. Following her academic years, Eshani was part of biopharmaceutical and contract research organizations (CROs), where she led LC-MS method development for bioanalysis of small and large molecules.
Eshani is currently a Global Technical Marketing Lead at SCIEX. She focuses on providing solutions to analytical challenges for biopharma quantitation and pharma applications by employing the latest mass spectrometry technologies.
This webinar was recorded on Thursday 29 June 2023.
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