Use of the RapidFire-MS/MS system for screening of topical formulations through the in vitro skin penetration assay

Agilent logoThe in vitro human skin penetration assay is a critical part of the development of topical products for dermatological use, as it allows the assessment of how much compound each formulation delivers into the skin. This assay has been redesigned using customized flow-through diffusion cells, enabling more reliable results and automated sampling into 96-well plates.

The integration of the RapidFire platform with Agilent’s 6490 triple quadrupole at Stiefel has enabled the use of a fully traceable analysis process in a “GLP-like” environment.
This webinar covers the following topics:

  • A new workflow for the in vitro skin penetration assay for topical/dermal product development.
  • How ultrafast SPE-MS/MS can dramatically increase the throughput of an ADME laboratory, while maintaining the same high quality data as UHPLC-MS/MS
  • How to reduce the time required to complete a larger number of samples
  • How to reduce the operational costs associated with analysis.

 

Speaker:

LSantos

 

 


Leandro Santos
Investigator, Center for Skin Biology
Stiefel, a GlaxoSmithKline company

Leandro joined Stiefel, a GlaxoSmithKline company, in 2005 and has worked in different areas including analytical development, formulation, preformulation and DMPK, with focus in both Rx and Cx topical product development. He has co-authored nonclinical sections of regulatory submissions and collaborated on protocols for clinical (Phase 1) studies. Leandro currently leads the Drug Delivery and Bioanalytical group, which is responsible for all NCEs and formulation screening for dermal programs at GlaxoSmithkline. He holds a double major in Pharmaceutical Sciences and Biochemistry and is also pursuing his graduate degree in Analytical Chemistry at University of North Carolina, Chapel Hill, under the supervision of Dr Gary Glish.