Volumetric absorptive microsampling–LC–MS/MS assays for quantitation of giredestrant in dried human whole blood

Johnson R, Rehmani I, Leahy M, et al. | Bioanalysis, 14(21), 1377 - 1389, (2022) Keywords: • anticoagulant • hematocrit • LC–MS/MS • microsampling • Mitra • Tasso-M20 • validation • VAMS • whole blood Volumetric absorption microsampling devices offer minimally invasive and user-friendly collection of capillary blood in volumes as low as 10 μl. Herein we describe the assay validation for determination of the selective estrogen receptor degrader giredestrant (GDC-9545) in dried human whole blood collected using the Mitra® and Tasso-M20 devices. Both LC–MS/MS assays met validation acceptance criteria for the linear range 1–1000 ng/ml giredestrant. Mitra and Tasso-M20...