Validation of Mitra® VAMS® as a blood collection technique for trace elements analysis using ICP-MS/MS

Breton A, Cirtiu C, Muehlethaler C, Rudge J, Fleury N | Bioanalysis, 16(04), 203-217, (2024) Keywords: • ICP–MS/MS • Method development and validation • Trace elements • VAMS • volumetric absorptive microsampling • whole blood Background: Clinical dosage of toxic and essential elements in blood is well established and the collection method is still by venipuncture. This method has drawbacks and is not suited for everyone. Volumetric absorptive microsampling (VAMS) has been shown to have advantages over venipuncture. Materials & methods: Using inductively coupled plasma tandem mass spectrometry, a method for quantifying elements in whole blood sampled on VAMS was developed/validated. Method's performance was assessed by comparison with whole blood results. Results: Validation and performance assessment tests tend...