Use of dried blood spots to study excipient kinetics in neonates
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"The ESNEE project will examine the kinetics of key excipients in neonates and thereby help further define the value of DBS sampling... " Liquid pharmaceutical formulations for parenteral and enteral use generally contain the active pharmaceutical ingredient (API, also known as the ‘drug’) and a range of other chemicals. The other chemicals are known as excipients and are required to overcome the chemical, physical and microbiological challenges posed by developing a formulation that is of sufficient quality to be used in clinical practice. Excipients may be added to liquid formulations to increase solubility and stability of the API, for palatability...