The versatility in LC selectivity attainable with the silica base and associated bonded phases

“...silica hydride phases can simultaneously retain both polar and nonpolar solutes via parallel, but distinct, retention mechanisms.” Recently, there have been various mass spectrometric innovations for obtaining additional selectivity coming to commercial realization for quantitative bioanalysis. For instance, interfacing ion mobility spectrometry with tandem quadrupolar detection, or using a linear ion trap scan function to attain an extra fragmentation step to bolster the already imposing selectivity of regular SRM [1,2], also the increasing use of quantification using high-resolution mass spectrometry [3,4]. Tools like these ease the life of the bioanalytical scientist, and can of course make it even more interesting....