The most convenient and general approach for plasma sample clean-up: multifunction adsorption and supported liquid extraction

“Removing both phospholipids and proteins is key to the effectiveness of a clean-up procedure for plasma samples.” The vast number and increased diversity of molecular entities of drug candidates present new challenges to methodologies of bioanalysis in the process of drug discovery. Blood plasma represents a major sample form in bioanalysis, particularly in the area of drug metabolism and pharmacokinetic (DMPK) studies. Thousands of plasma samples need to be processed in DMPK of preclinical researches [1,2]. Therefore, it becomes some of our criteria in establishing a method of sample preparation that is simple, fast, efficient and high throughput. State-of-the-art technologies...