The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena

“Despite the recent widespread adoption and the benefits of using UHPLC–HRMS for drug metabolism, pharmacokinetics and metabonomic studies, challenges around automated user-friendly software tools, data file comparison techniques and ultimate quantitative sensitivity similar to triple quadrupole MS remain unconquered.” Today, high-resolution MS (HRMS) is used in many areas of science including the pharmaceutical industry. Looking back 100 years, a mass spectrometer with a mass resolving power of less than 20 was used by Sir Joseph John Thomson to discover electrons (1906 Nobel prize in physics). Thomson’s student, Francis W Aston, designed and built several mass spectrometers before constructing one with...