The BZ advent calendar

Written by Emma Hall (Editor)

Countdown to Christmas with our festive BZ advent calendar!

Did someone say Christmas? Time to pipette some holiday cheer! In this BZ advent calendar, we’ve collected some of our favorite content, as well as some exclusive pieces. Dive into some festivities below!

 

1 – Webinar fun on day one!

Challenges and opportunities for high-complexity flow cytometry in clinical trials

 

 

2 – Coffee chats brewed for you

Coffee chat: past, present and future of quantitative drug discovery practices

Coffee Chat: reporting requirements for ICH M10

 

3 – News spree

What if we could eliminate the need for lymphodepleting chemotherapy before CAR T-cell therapy?

15-minute heart attack detection: UCLA’s breakthrough paper-based test

A device that monitors health by wrapping around your finger? No sweat

4 – eBooks galore

eBook: The current bioanalytical landscape for biosimilars

eBook: Flow cytometry in cancer therapy development

eBook: vaccine development in clinical trials

eBook: Bioanalysis of Antibody Drug Conjugates by LC/MS: Challenges and Solutions

5 – Achievements from 2024

FDA approved: the first hemophilia A gene therapy authorized for the United States

Breakthrough blood test detects deadly brain cancers in just 60 minutes

FDA-approved AI-driven tool for sepsis diagnosis

New monoclonal antibody treatment for malaria: a breakthrough on the horizon?

Big breakthrough in small science: new MS technology could reshape sample analysis

6 – Event picks

18th EBF Open Symposium

2025 AAPS PharmSci 360

26th International Reid Bioanalytical Forum

19th WRIB

TIDES Asia 2025

DIA 2025

7 – Podcast heaven

The new frontier: assessing efficacy and safety of CGTs using biomarkers

The new frontier: immunogenicity testing for cell and gene therapies

Challenges and solutions in monitoring assay performance for vaccine development: an interview with Atul Chaudhari

ADA detection and characterization for immunogenicity testing: insights from ICON’s Lindsay Denhoff

The new frontier: regulatory implications for cell and gene therapies

The new frontier: qPCR vs ddPCR for cell and gene therapies

Beyond the Abstract: an interview with Hetal Sarvaiya and Yuting Wang

8 – Articles to celebrate

Can capillary microsampling facilitate a clinical pharmacokinetics study of cefazolin in critically ill children?

A European Bioanalysis Forum recommendation for requiring a context-of-use statement for successful development and validation of biomarker assays

Development and validation of carbodiimide-activated ELISA plate for quantifying IgG levels against Streptococcus pneumoniae capsular polysaccharides

Western blotting: evolution of an old analytical method to a new quantitative tool for biomarker measurements

Solving selectivity issues in LBAs: case study using Gyrolab to quantify CB307, a bispecific Humabody in human serum

Validation of Mitra® VAMS® as a blood collection technique for trace elements analysis using ICP-MS/MS

A blood-based, metabolite and demographic characteristic markers panel for the diagnosis of Alzheimer’s disease

BiSim Tool: a binding simulation tool to aid and simplify ligand-binding assay design and development

9 – Infographics that shine

Infographic: Doping at the Olympic Games – past, present and future

Infographic: Immunogenicity assessment of therapeutic proteins

Infographic: Assay monitoring – the importance of performance and maintenance

Infographic: Evolving best practices in flow cytometry to support biomarker analysis in drug development

Infographic: Bioanalytical support for AAV therapies

Infographic: The Essentials of Sample Preparation

Infographic: monoclonal antibody production strategies using phage display vs in vivo immunization

Infographic: Gyrolab® hybridization assays for oligonucleotide analysis

Infographic: considerations around validation of methods for hybrid LC–MS/MS assays using non-primary matrices

10 – eBooks again!

Technology Digest: Antibody engineering and SpyTag-SpyCatcher technology

eBook: adapting to an evolving drug modality landscape

Technology Digest: Transforming drug development with label-free, kinetic-based assays

Technology Digest: the trials and triumphs in oligonucleotide bioanalysis

eBook: Antibody–drug conjugate bioanalysis

 11 – Expert insights

Working with a CRO: Sara Underwood on bioanalytical and PK projects

Understanding how biologics trigger immune responses: T-cell-dependent vs T-cell-independent pathways

The bioinert revolution

12 – One for the bioanalysis elves

Evidence of a Christmas spirit network in the brain: functional MRI study

Mass spectrometry to catch Christmas tree thieves and timber traffickers

The effect of having Christmas dinner with in-laws on gut microbiota composition

Christmas-Related Reduction in Beta Activity in Parkinson’s Disease

13 – Techniques to enhance your research team

The origin-adjusted approach for biomarker quantification by LC–MS

Unraveling O-glycosylation patterns with mucinases and mass spectrometry

Best practices in qPCR and dPCR validation in regulated bioanalytical laboratories

From brain biopsies to liquid biopsies: a next-generation platform using extracellular vesicles to detect brain disorders

The power of virtual screening for identifying small molecule drug candidates

14 – Events foreseen

Society of Toxicology Annual Meeting and ToxExpo 2025

18th European Biosimilars Congress

World Vaccine Congress 2025

Immunology 2025

15 – Graphics to be admired

Survey infographic: benefits and challenges of biomarker studies for oncology drug development

Infographic: iChem Workflow – Current advancements in automation and future hurdles

Infographic: the use of ELISpot assays for evaluating the safety of therapeutic drugs

16 – A knowledge stream

Sweat tech: the latest microfluidic patch for measuring trace perspiration

Advanced DDT-IMS technology speeds up detection of TNT-derived metabolites

New US Pharmacopeia guidelines could transform biologics impurity control

Using a fingerprint for non-invasive drug monitoring

 17 – Top tips for your research team

Tips and tricks: how to streamline compliance in a regulated pharmaceutical laboratory

Evolving best practices: considerations for conventional and spectral flow

Top tips for PhD applications: an interview with Melanie Bailey

18 – Discussions to deepen your bioanalysis esteem

Panel discussion: LBA and LC–MS/MS hybrid assays

Panel discussion: challenges and advances in AAV therapy bioanalysis

Challenges and opportunities for high-complexity flow cytometry in clinical trials

Panel discussion: immunogenicity assessment of therapeutic proteins

Panel discussion: overcoming the unique bioanalytical challenges of supporting complex, regulated clinical studies

19 – Breakthroughs shaping the bioanalysis stream

Rapid generation of bispecific antibodies for high-throughput screening with SpyLock technology

Innovative biomarker panel boosts early pancreatic cancer detection

Emerging imaging technology improves stroke surveillance and accurately predicts recovery

20 – Talks aplenty

Using the Gyrolab® platform for oligo quantification: an interview with John Chappell

Beyond the Abstract: an interview with Gaudry Troché

The new frontier: using LC–MS/MS for quantitative assays to support gene therapies

Precision oncology: an interview with Karina Eterovic

The new frontier: ddPCR for cell therapies

Molecular Moments: Neil Spooner Talks Bioanalysis, Microsampling and Homemade Jam!

21 – An award to be won..?

Bioanalysis Rising Star Award 2025: why nominate?

 

 

22 – Expert points of view

Ask the Experts: the importance of data cleaning in laboratory operations

Ask the Experts: the impact of internal standard response variability during chromatographic bioanalysis

Ask the Experts: organization and transformation of bioanalytical data for PK analysis

Ask The Experts: the impact of COVID-19 on the lab

23 – Videos to watch

Piet van der Graaf on AI and AI-assisted approaches in drug discovery & development

Challenges and future opportunities in the clinical trial landscape: an interview with Tom Zhang

Bioanalysis Rising Star Award: an interview with the 2024 winner

24 – Moments to explore

Black History Month: an interview with Rene Fuanta

International Women’s Day 2024 with Jennifer Zimmer

Advice to my younger self with Fern Adams-Dam and Burcu Uner

HeLa cells take the prize: BHM art competition winner announced!