Technology Digest: Antibody engineering and SpyTag-SpyCatcher technology
Antibodies are among the most frequently used research tools in clinical assays and are incredibly valuable for basic scientific research. Over the last few years, there has been a lot of development in the methods and techniques used for antibody engineering, resulting in recombinant antibody formats, such as Fab (fragment antigen binding) fragments, becoming more widely available e.g. for use in immunoassays. During drug development it is important to analyze and quantitate protein biotherapeutics to support pharmacokinetics, pharmacodynamics, and safety assessments. Large biological analytes, such as antibodies, are typically measured using ligand-binding assays in immunoassay formats, for example ELISA. Immunoassays use the specificity of an antigen-antibody interaction to quantify and detect target molecules within a sample and immunoassay platforms use at least one antibody or antigen, as well as binding reagents that possess specificity for the analyte.
In this eBook, we explore antibody engineering, the importance of high-quality antibody formats and the benefits of SpyTag-SpyCatcher technology.
This eBook includes:
- TECHNOLOGY DIGEST: Antibody engineering and SpyTag-SpyCatcher technology
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PERSPECTIVE: Critical reagent generation, characterization, handling and storage workflows: impact on ligand binding assays
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METHODOLOGY: Characterization of robust immune responses to a bispecific antibody: a novel class of antibody therapeutics
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WHITE PAPER: Guide to SpyCatcher products supporting TrailBlazer Antibodies
- WHITE PAPER: TrailBlazer Antibody custom services
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