Tech Digest

Aiming to provide a deep dive into a technology or technique, our Tech Digests place the chosen technology in the context of the wider industry in an editorial-style, 1000–1500-word article. Each Tech Digest highlights the key applications, advantages and drawbacks compared to alternative technologies. Packaged in a downloadable eBook format, you get access to the Tech Digest as well as related articles from our journal collection.

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Technology Digest: Transforming drug development with label-free, kinetic-based assays

Ligand-binding assays (LBAs) are kinetic-based assays widely used to measure interactions between two molecules, such as proteins, antibodies and many others. They are considered the ...

Technology Digest: the trials and triumphs in oligonucleotide bioanalysis

During the last decade, there has been considerable evolution in the target modalities contributing to the development of pharmaceutical medicines. Joining established pipelines of ...

Technology Digest: Antibody engineering and SpyTag-SpyCatcher technology

Antibodies are among the most frequently used research tools in clinical assays and are incredibly valuable for basic scientific research. Over the last few years, there has been a lot ...

Technology Digest: Free versus total analyte quantification using ligand-binding assays

Drug development is fundamentally supported by preclinical and clinical study data, which measure accurate quantitative biotherapeutic drug concentrations. The data generated by the ...

Technology Digest: HCP detection and quantitation: a review of ELISA, MS and Antibody Affinity Extraction immunoaffinity chromatography

In the context of biological drugs, host cell proteins (HCPs) represent a heterogeneous group of process-related impurities. Whilst many are benign, some HCPs are immunogenic, meaning ...

Technology Digest: the role of digital data management in today’s collaborative drug discovery approach

Background The initial stages of drug discovery and preclinical testing represent some of the most labor intensive, and therefore costly, phases of drug development, with just 0.02% of ...

Technology Digest: single-analyte biomarker assays for pharmacodynamic or safety assessment during biotherapeutic development

When used to make decisions concerning regulatory submissions and drug development, it is essential that biomarker assays deliver high performance and reliability. As development ...

Technology Digest: defining specificity within the ELISpot assay

The enzyme-linked immune absorbent spot (ELISpot) assay provides important information on the abundance of low frequency immune cells, with an emphasis on the detection of ...

Technology Digest: LBAs vs chromatographic platforms for oligonucleotide quantification

Background Oligonucleotides are, in essence, nucleic acid polymers that have the potential to treat a vast array of diseases, acting as therapeutics that predominantly focus on gene ...

Technology Digest: flow cytometry for high-throughput antibody screening

Antibody-based therapeutics, such as monoclonal antibodies (mAbs), have become important treatment modalities for human diseases. Antibody-based drugs have been investigated in a wide ...

Technology Digest: understanding drug–protein binding and ADME studies for DMPK

DMPK: what is it? In drug development, DMPK studies are performed throughout the development process in order to determine the pharmacological characteristics of a drug candidate, with ...

Technology Digest: implementation of automation, IT support and cybersecurity in bioanalysis

The use of automation in the bioanalytical laboratory Automated tools and platforms have benefited the bioanalytical laboratory by reducing method development and data turnaround times. ...

Technology Digest: effective biomarker measurement is key for biotherapeutic development

Poster | Download the eBook Biomarkers and their role in drug development A hybrid of the word ‘biological marker’, biomarkers are a biologic or physiological characteristic that can ...

Technology Digest: immunoassay automation is driving advancements in cell and gene therapies

Interview | Download the eBook Reaping the benefits of immunoassay automation The advancement of CGT is driven by process improvements and technological innovations resulting in faster ...

Technology Digest: Nitrosamine Impurities – From Raw Materials to Final Drug Product

Podcast | Infographic | Download the eBook | Webinar What are nitrosamines? Nitrosamines are a class of mutagenic impurities which contain the nitroso functional group and are formed ...

Technology Digest: the bioanalytical tools that support cell and gene therapy development

More resources Interview | Download the eBook The promise of cell and gene therapies Cell and gene therapies are promising new therapeutic modalities used in the treatment of inherited ...

Technology Digest: why is it important to develop a critical reagent management strategy?

More resources Interview: critical reagents with Ashley Brant | Webinar: Critical Reagent Management Strategies | Download the eBook The importance of critical reagents When making ...