The practical challenges of new modalities in bioanalysis

Hybridization assays are readily used as bioanalytical tools to support pharmacokinetic, toxicokinetic and animal biodistribution studies for oligonucleotide drug programs. Reliable, robust and reproducible bioanalytical quantitation is critical in projecting clinical dose treatments.

This Spotlight will explore the various ligand binding assay formats used for measuring non-viral vector gene therapies, namely therapeutic oligonucleotides that are currently in development. Additionally, we will discuss the general and critical features of specific quantitative bioanalytical techniques (e.g., chromatographic techniques and hybridization-based ELISAs), along with a comparison of the relative advantages and limitations of such methods, as well as considerations for their routine application to the various oligonucleotide classes.

This feature was produced in association with Charles River

Want to find out more about Charles River’s services? Check out the links below:

Ligand Binding Assay Bioanalysis
ELISA & Immunoassay Development