Automation

Automation can increase throughput while maintaining quality; this increase in efficiency can lead to a reduction in the cost of bioanalysis. Along with many other benefits, automation also eliminates bottlenecks and improves workflows, making it a key area of interest for bioanalysts.

In this Spotlight we will explore various aspects of automation, from sample preparation to incurred sample reanalysis and data management.

We will discuss key issues in this field, such as: the main barriers to implementation of automation; the potential for increased focus on downstream automation; and whether increased collaboration between robot manufactures and bioanalysts is beneficial?

We will ask leading experts for their views on critical issues; we hope their responses will provide valuable insight into this constantly evolving field.

Articles

Automation in Chinese bioanalytical CROs for sustained competitiveness and growth
Validation of an integrated series of ligand-binding assays for the quantitative determination of antibody–drug conjugates in biological matrices
Small-molecule bioanalytical sample preparation method development starting from the BASICS
Online and automated sample extraction
DBS direct elution: optimizing performance in high-throughput quantitative LC–MS/MS analysis
HT-ADME in a contract research organization laboratory: can you ensure bioanalytical quality in a highly automated environment?
Automated direct extraction and analysis of dried blood spots employing on-line SPE high-resolution accurate mass bioanalysis
Current advances and strategies towards fully automated sample preparation for regulated LC–MS/MS bioanalysis
The Gyrolab™ immunoassay system: a platform for automated bioanalysis and rapid sample turnaround
Bioanalytical laboratory automation development: why should we and how could we collaborate?
Ask the Experts: Automation: Part I
Laboratory automation of high-quality and efficient ligand-binding assays for biotherapeutic drug development
Automation in the bioanalytical laboratory: what is the future?
A generic template for automated bioanalytical ligand-binding assays using modular robotic scripts in support of discovery biotherapeutic programs

Insights

In the Zone: data management
Integrated Automation Delivers Reproducible Results
Automation in Chinese bioanalytical CROs for sustained competitiveness and growth
Interview with Rob Durham (Gyros) on automation of assays and the Gyros Immunoassay
Automation and Logistics
Webinar Q&A follow up: ‘High-throughput mass spectrometric analysis of covalent protein-inhibitor adducts for the discovery of irreversible inhibitors: a complete workflow’
HT-ADME in a contract research organization laboratory: can you ensure bioanalytical quality in a highly automated environment?
Commentary on the Automation survey results
Expanding the notion of automation in bioanalysis, end-to-end
Automation survey infographic
Laboratory automation: letting scientists focus on science

Webinar

Automation enabled Hybrid LBA/LC–MS Biologics Bioanalysis with the BioBA Solution
High-throughput mass spectrometric analysis of covalent protein-inhibitor adducts for the discovery of irreversible inhibitors: a complete workflow
Automated nanoliter-scale immunoassays to increase efficiency and productivity in bioanalysis
Panel discussion on automation

Interviews

Interview with Benno Ingelse (Q² Solutions) on automation benefits
Interview with Benno Ingelse (Q² Solutions) on the challenges of automation in the lab
Interview with Rob Durham (Gyros) on automation of assays and the Gyros Immunoassay

Resources

Automation survey infographic
Product: Automated nanoliter-scale immunoassays (Gyros)
Video: Gyrolab xPlore™ (Gyros)
Application note: Maximizing productivity in Biopharmaceutical research and clinical development (Gyros)
Application note: Miniaturizing immunoassays for improved performance (Gyros)