Specificity versus selectivity: twin aims of aptasensors in bioanalysis

In the current era of bioanalysis, the most challenging task is to overcome the tussle between specific and selective receptors as these two provide different but complementary strategies. Now the question arises, can bioanalysis be aimed without convergence of specificity and selectivity? Is it possible to converge both the strategies? Let's discuss the merits and challenges of bioanalysis in terms of specificity versus selectivity in order to find the solutions. Specificity in its ideal form denotes the bioanalysis which is completely specific to only one analyte without recognizing any other analyte. Bioconjugation pairs (such as, streptavidin/biotin, antibodies enzymatic lock-and-key and...