Single-drop microextraction for bioanalysis: present and future

“MALDI-MS has been proved as the key technology for quantitative and qualitative analysis of biomolecules in proteomics and genomics.” Intensive efforts have been devoted to the development of miniaturized analytical tools for analysis of various biomolecules, such as proteins, mixtures of proteins and nucleic acids and protein digests. The separation and sensitive detection methods are the core of the field in proteomics, genomics and modern biology. The detection of biomolecules such as amino acids, peptides, proteins, nucleic acids and related substances in biological samples (blood, urine, tissues, cells and microorganisms) is collectively known as bioanalysis. Biological samples are complex mixtures,...