Sample preparation in capillary electrophoresis for the determination of small molecule drugs and metabolites in urine

Muhandiramge R, Quirino JP | Bioanalysis 13(7), 533–536 (2021) Keywords: at-line • capillary electrophoresis • drugs • in-line • metabolites • off-line • on-line • sample preparation • stacking • urine Capillary electrophoresis (CE) is a microscale analytical separation technique which utilizes the power of the electric field to separate charged or neutral analytes inside a narrow inner diameter capillary (typically a 50–75 μm inner diameter fused silica capillary). The simple CE instrumentation is available commercially, and offers straightforward operation, high separation power, fast analysis times, small sample and reagent requirements – making CE an appealing tool for analysis of complex biological samples. Indeed, CE...