Recent advances in chiral analysis for biosamples in clinical research and forensic toxicology

Chen L, Zhu D & Xiang P | Bioanalysis, 13(6), 493 - 511, (2021) Keywords: • chiral analysis • chromatography • clinical research • forensic toxicology • sample pretreatment This article covers current methods and applications in chiral analysis from 2010 to 2020 for biosamples in clinical research and forensic toxicology. Sample preparation for aqueous and solid biological samples prior to instrumental analysis were discussed in the article. GC, HPLC, capillary electrophoresis and sub/supercritical fluid chromatography provide the efficient tools for chiral drug analysis coupled to fluorescence, UV and MS detectors. The application of chiral analysis is discussed in the...