Rapid immune-profiling displacement assay developed to assess immune response

Researchers report on a novel deterministic lateral displacement (DLD) assay able to rapidly assess inflammatory responses in the host. This would allow patients exhibiting life-threatening immune responses to be identified for rapid treatment. The label-free assay was developed by a team from Critical Analytics for Manufacturing Personalized-Medicine, an interdisciplinary research group at the Singapore MIT Alliance for Research and Technology (Singapore). The assay, which uses L- and inverse-L-shaped pillars of DLD microfluidic technology, can quantify and profile the immune states of white blood cells. It does this by assessing the biophysical properties of the cells, requiring only 20 microliters of...