Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective
Baldwin J, Piplani S, Sakala IG, Honda-Okubo Y, Lei L, Petrovsky N | Bioanalysis, 13(24), 1805–1826 (2021) Keywords: analytical tools • COVID-19 • pandemic • preclinical models • SARS-CoV-2 • vaccine design • viruses Vaccines are key in charting a path out of the COVID-19 pandemic. However, development of new vaccines is highly dependent on availability of analytical methods for their design and evaluation. This paper highlights the challenges presented in having to rapidly develop vaccine analytical tools during an ongoing pandemic, including the need to address progressive virus mutation and adaptation which can render initial assays unreliable or redundant. It also discusses...