Quantification of the antibody drug conjugate, trastuzumab emtansine, and the monocolonal antibody, trastuzumab in plasma using a generic kit-based approach

This application note describes the total mAb quantification of the ADC, ado-trastuzumab emtansine, and the mAb, trastuzumab from rat plasma using the ProteinWorks eXpress Direct Digest Kit and Protocol.

The ProteinWorks eXpress Direct Digest Kit was successfully used to quantify trastuzumab and the ADC, T-DM1 from a typical set of standard curve and QC samples in plasma. The universal, kit-based approach allows novice users to achieve high sensitivity with a simple step-wise protocol and standardized, premeasured reagents, ensuring both the sensitivity and reproducibility required in discovery studies to make time sensitive and critical project decisions.

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