Merck: SILu™Prot

A novel collection of stable isotope-labeled (SIL, or “heavy labeled”) full length proteins designed to be used as mass spectrometry internal standards for quantitative proteomics. The ideal method of optimizing reproducibility and accuracy in protein quantification by mass spectrometry is to add a full length SIL recombinant protein, equivalent to the native target protein, to the sample at the initial stage of sample preparation. Introduction of an internal standard at the beginning of the MS workflow minimizes variations in quantification due to protein extraction, fractionation, enrichment, proteolysis and analysis. Sigma-Aldrich also offers all of the SILu™Prot products in their unlabeled form, SILu™Lite.

For more information, visit sigma-aldrich.com/siluprot