Merck: Ascentis® Express Products: Columns that use combined technology

Phenyl-Hexyl HPLC Columns

The phenyl phase has unique reversed-phase selectivity, especially for polar aromatics and heterocyclic compounds, arising from solute interaction with the aromatic ring and its delocalized electrons. Ascentis® Express Phenyl-Hexyl is complementary (orthogonal) to both C18 and RP-Amide Ascentis Express phases because of this unique aromaticity. Phenyl phases also tend to exhibit good shape selectivity, which may originate from solute multipoint interaction with the planar ring system. More retention and selectivity will often be observed for solutes with aromatic electron-withdrawing groups (fluorine, nitro, etc.) or with a delocalized heterocyclic ring system such as the benzodiazepine compounds.

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ES-Cyano HPLC Columns

Ascentis® Express ES-Cyano HPLC column is a high-speed, high-performance liquid chromatography column based on 90Å Fused-Core® particles. The Fused-Core particle provides a thin porous shell of high-purity silica surrounding a solid silica core. This particle design exhibits very high column efficiency due to the shallow diffusion paths in the 0.5-micron thick porous shell and the small overall particle size of 2.7-microns. The sterically protected, extensively endcapped diisopropyl-cyanopropylsilane stationary phase of Ascentis Express ES-Cyano provides a stable, reversed-phase packing that can be used for basic, acidic, or neutral compounds.

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