Bio-Rad: Anti-hIgG Fc antibodies for generic PK assays

Website: https://www.bio-rad-antibodies.com/anti-human-igg1-fc-r10z8e9-alternative.html

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Bio-Rad offers two antibody clones specific to human IgG Fc that can be used to detect human or humanized therapeutic antibodies in non-human primate samples.

Clone AbD27686 (HCA285) is a recombinant monovalent Fab antibody, specific to human IgG1 Fc, with greatly reduced affinity for IgG from cynomolgus macaque compared to human IgG1, and strongly reduced binding to rhesus macaque IgG. It does not recognize other human immunoglobulin (Ig) isotypes or mouse IgG2a.

Clone R10Z8E9 (MCA5748G) is a mouse monoclonal antibody specific to human IgG CH2 domain. It has been demonstrated by ELISA not to recognize IgG from the non-human primate species baboon, marmoset, rhesus and cynomolgus macaques; nor does it recognize mouse or rat immunoglobulin.

Find out more about Bio-Rad’s Anti-hIgG Fc Antibodies