Product: Vion IMS QTof
The integrated ion mobility capabilities of the Vion IMS QTof provide enhanced separation power, delivering clearer data and
reducing the possibility of missing drug metabolites. Using ion mobility-enabled data independent acquisitions, Vion provides MS-MS quality product ion spectra and removes the need for additional MS-MS or data dependent acquisitions (DDA). This reduces analysis time and allows rapid identification of metabolites. The collisional cross section (CCS) values generated from ion mobility separation (IMS) data can be used to track and confirm metabolites throughout discovery and development and are particularly valuable for isomeric metabolites, which cannot be distinguished by chromatography.
When ion mobility-enabled, non-targeted MSE acquired data is coupled with intelligent data compression and processed using Mass-MetaSite and WebMetabase metabolite ID software, key cyclic peptide metabolites can be routinely identified and elucidated. Intelligent data capture reduces file size by more than 70%, while the macromolecule processing settings for Mass-MetaSite and WebMetabase make possible access to and analysis of IMS-enabled DIA (HDMSE) data directly from the UNIFI software platform. Comprehensive metabolite identification of complex cyclic peptides is achieved by combining IMS data with a powerful software solution tailored for macromolecules.
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Somatostatin analogue catabolite screening and identification using Vion IMS QTof with WebMetabase
