Poster: Ultra-Sensitive Quantitation of pg/mL Level Exenatidewith Trap-and-Elute Micro-Flow LC/MS/MS (AB SCIEX)
LC/MS method has been chosen preferably for the quantitation of Exenatide in biological samples due to the advantages in excellent selectivity, sensitivity, wide analytical and reproducibility. To further extend lower limit of quantitation (LLOQ) to accurately study lower concentration exenatide in plasma samples (<100 pg/mL), a microflow trap-and-elute LC/MS/MS method was developed and demonstrated here with LLOQ at 2 pg/mL and excellent linearity, quantitation accuracy and precision, as well as low system carryover.
