Poster: Improved Sensitivity, Resolution and Speed for Lipid Profiling using Microflow Liquid Chromatography (AB SCIEX)

To improve the sensitivity, resolution and speed for lipid profiling and quantitation, a high flow LC with high resolution mass spectrometry method was converted to a microflowmethod where significant sensitivity improvement was observed with an average of 24-fold improvement for monitored internal standards with 1/10 of on column injectoin. Besides the sensitivity gain, better chromatographic resolution, 2-fold throughput improvement and less sample and solvent consumption were also observed.

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