Poster: developing a sensitive LC–MS assay for measuring thyroid hormones

INTRODUCTION

Drugs and chemicals have the potential to perturb thyroid hormone homeostasis with associated deficits in neurological development and function. Guidelines published by the Organization for Economic Co-operation and Development (OECD), as well the US EPA, require the evaluation of circulating levels of T3, T4, and thyroid stimulating hormone (TSH) in fetal (Gestation Day (GD) 20) and neonatal specimens to address this risk. Sensitive assays capable of measuring T3, T4, and TSH are required and traditional electrochemiluminescent immunoassays (ECLIA) are inadequate. In response, a highly sensitive LC-MS/MS method was developed.

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