Pharmacokinetic drug–drug interactions: an insight into recent US FDA-approved drugs for prostate cancer

Gajula SNR, Reddy GN, Reddy DS, Sonti R | Bioanalysis. 12(22), 1647–1664 (2020) Keywords: combination therapy • CYP enzymes • drug–drug interactions • prostate cancer • transporters Pharmacokinetic drug–drug interaction is a significant safety and efficiency concern as it results in considerable concentration changes. Drug–drug interactions are a substantial concern in anticancer drugs that possess a narrow therapeutic index. These interactions remain as the principal regulatory obstacle that can lead to termination in the preclinical stage, restrictions in the prescription, dosage adjustments or withdrawal of the drugs from the market. Drug metabolizing enzymes or transporters mediate the majority of clinically relevant drug...