New methodology for the development of chromatographic methods with bioanalytical application

“There should be room in bioanalytical laboratories for the most promising statistical methodologies available, in the same way that analysts in these laboratories have acute analytical technologies available.” Bioanalytical methods are developed in order to answer the analytical problems faced by analysts. The analytical issues that must be solved are generally the detection and/or quantification of an active ingredient in biofluids, their metabolites or the monitoring of endogenous compounds. From the palette of analytical techniques available to develop a bioanalytical procedure, LC is widely used. Since the works of Tswett, which led to the birth of chromatography [1] and the...