Monitoring of hemoglobin and erythropoiesis-related mRNA with dried blood spots in athletes and patients

Loria F, Stutz A, Rocca A, et al. | Bioanalysis, 14(5), 241 - 251, (2022) Keywords: • anti-doping • dried blood spots • hemodialysis • hemoglobin • mRNA • reticulocyte Aim: We assessed the feasibility of using hematological parameters (such as hemoglobin and reticulocyte mRNA) in dried blood spot (DBS) samples to test athletes for doping and to improve patient care. Methods: Hemoglobin and erythropoiesis-related mRNAs were measured in venous blood and DBSs from both healthy athletes and hemodialysis patients. Results: We accurately measured hemoglobin changes over time in both venous blood and DBS samples. Combining hemoglobin and mRNA analyses,...