Matrix factor: a ratio a little too divisive?

In this column from Robert MacNeill (Labcorp Drug Development, NJ, USA), he explores matrix factor testing, and how it is designed to assess to what extent the LC–MS signals for all the monitored compounds of interest are altered in the presence of residual matrix components that pass through the sample extraction. Robert MacNeill received his Bachelor’s degree with Honors in Chemistry from Heriot Watt University then his MSc in Analytical Chemistry from the University of Huddersfield, both in the United Kingdom. Robert is also a Chartered Chemist and a Fellow of the Royal Society of Chemistry. With 22 years of...