Manual chromatographic baseline integration: is it needed, if so when should it be used?

“...when is it appropriate to reject the ‘integrator’ results? If reintegration is necessary, how do you set objective and consistent procedures tominimize bias at the best and fraud at the worst?” The objective of this article is to discuss the prevailing opinions on whether chromatographic baselines should be determined by setting the “integrator” (integration algorithm) parameters and accepting this data only or when there are situations where the integrator does not get it right and further evaluation is necessary. The issues arise largely in the second case. When is the data not acceptable, that is, when is it appropriate to...