MALDI imaging MS analysis of drug distribution in tissue: the right time!(?)

“The application of MALDI-IMS to determine the tissue distribution of drugs and their metabolites is the type of innovative technology that can have a dramatic impact on both drug discovery and development.” The goal of pharmaceutical companies is to develop and market safe and efficacious drugs for unmet medical needs. Continuous improvements in technology and the accumulation of scientific knowledge should facilitate more effective means to achieve this goal. Unfortunately, there has been a significant decline in the number of new medicines approved, and at the same time the cost of research and development has soared [1]. Consequently, there is...