In situ drug and metabolite analysis in biological and clinical research by MALDI MS imaging
A microscopic image of an organoid model of thyroid cells mimicking the natural organization and function of the thyroid gland for hormone production studies.
In recent years the analysis in mass spectrometry (MS) imaging has been expanded to detect a wide variety of low molecular weight compounds (LMWC), including exogenous and endogenous compounds. The high sensitivity and selectivity of MS imaging combined with visualization of molecular spatial distribution in tissues, makes it a valuable platform in targeted drug and untargeted metabolomic analysis in biological and clinical research. Here, we review the current and potential applications of MALDI MS imaging in these areas. The aim of advancing MALDI MS imaging in the field of LMWC is to support clinical applications by understanding drug and drug-metabolite...
