Hybrid stationary phases: the answer to all of your matrix effect problems?

“The hybrid stationary-phase approach has been reported to merge the simplicity of protein precipitation-only procedures with the selectivity of SPE.” Matrix effects can result in proportional errors in quantitative measurements by MS. They are commonly caused by signal enhancement or suppression resulting from co-elution of matrix components that compete with the target analyte for ionization or contribute to their ionization efficiency [1,2]. These components are often undetected at the mass transitions used for analysis, but can significantly affect analyte sensitivity and reproducibility [3]. Matrix effects can be of particular concern due to variability in the concentrations of matrix effect-causing components...