Hybrid LC–MS as a powerful tool for supporting protein bioanalysis in gene and cell therapies

D Wei , Y Kim, H Sugimoto, L Dong & M G Qian | Bioanalysis, 12(14), 977-979 (2020) Keywords: • bioanalysis • cell therapy • gene therapy • hybrid LC–MS Gene and cell therapies are promising new therapeutic modalities for treatment of inherited and acquired diseases [1]. In gene therapy, exogenous DNA or RNA are introduced into targeted cells via a viral vector or a nonviral carrier to override the faulty gene and restore its normal function. In cell therapy (for example, chimeric antigen receptor T cell [CAR-T]), autologous or allogenic immune cells engineered ex vivo to express target receptors...