How useful is ICP-MS for determining PK properties of metal-based drugs?

“The multi-elemental capability of ICP-MS provides the unique possibility to obtain comprehensive chromatograms/electropherograms of different elements.” LC and GC coupled to MS based on soft atmospheric ionization techniques are considered as the major tools, next to NMR spectroscopy, for medical diagnostics and PK studies [1]. The substantial advancement of LC to ultrafast LC, and MS with improved resolving power, acquisition speed and mass accuracy (below 1 ppm) has vastly improved the efficiency of new drug development [2]. Molecule-specific MS and spectroscopy give the unique ability to obtain comprehensive metabolite profiles from different biological fluids, or to search for alterations in...