High sensitivity quantification of Infliximab in rat plasma using a fast, standardized kit-based approach

Chromatography MS (LC–MS/MS, HRMS, IMS)

This application note describes the fast, sensitive quantification of infliximab from rat plasma using the ProteinWorks eXpress Digest Kit and Protocol.

The ProteinWorks eXpress Digest Kit was successfully used to purify infliximab from a typical set of standard curve and QC samples in rat plasma. A limit of quantification of 10 ng/mL was readily achieved, while maintaining excellent linearity and single digit precision.

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