Existing COVID-19 test may not predict protection against reinfection

Researchers from The University of Texas (TX, USA) have explained two different types of detectable antibody responses to the SARS-CoV-2 virus that may indicate different outcomes in relation to protection against reinfection of COVID-19. Antibodies to the SARS-CoV-2 spike protein receptor binding domain (S-RBD) are speculated to neutralize the virus infection, however, antibodies to the SARS-CoV-2 nucleocapsid protein (N-protein) may indicate exposure to the virus but not protection against reinfection.  Therefore, the team have recommended caution against the extensively used N-protein based serology tests for determining potential COVID-19 immunity. In their experiment, recently described in JCI Insight, the team generated...