EBF 10th Open Symposium

Event details

Website:
Location: Hotel NH Collection Barcelona, Gran Via 144. 08907 Hospitalet de Llobregat, Barcelona, Spain, Europe
About

For the 10th symposium, EBF have planned to increase connectivity by making more time available for interactive workshops and increased time for discussions during the plenary presentations.

We identified 5 themes for plenary presentations and 5 themes for interactive workshops for which we have reserved ½ day on day 2.

  1. Our Daily Challenges:
    • Globalization of BA – any challenges along the road?
    • Learning from mistakes – your worst BA nightmare shared in Barcelona
    • Efficient assay transfer – a smooth journey?
    • What if ISR really fails?
  2. Regulations:
    • Feedback from industry experience during filings – what questions did you get, how did you overcome challenges?
    • How do we manage new technologies or assay formats in a regulated environment?
    • New guidelines impacting the BA landscape dissected to agree on a common approach (e.g. OECD-17, GLP, Data integrity…)
  3. New Technologies Embraced versus Established Technologies Refined
    • Novel solutions for daily challenges: game changers on the horizon?
    • Bedside monitoring – a new hype or here to stay?
    • How quantitative are imaging data? Can we validate them? Should we?
    • Can the latest developments in Ligand Binding, Chromatography and Hybrid Assays be applied routinely?
  4. The Challenges from 2016 Continue….
    • Biomarkers:
    • Use and Validation of ‘quasi-quantitative’ assays (LBA, enzyme-activity, receptor occupancy, FACS)
    • The weak boundary between exploratory and confirmatory biomarker
    • Immunogenicity – best practices and continued challenges
    • Scientific Validation – implementation in a global setting
  5. How can we do More with Less?
    • Honey, they shrunk the budget!
    • Single analysis in LBA – why aren’t we doing it?
    • Analyzing placebos, taking duplicate samples – why do we keep on doing it?

Five themes for the Interactive Workshops:  Workshops related to (1) the E-environment, (2) technology development, (3) specialized sampling or separation developments, (4) specialized LBA and (5) practical challenges with regulations

Register here.

Highlights from our Partners

SciexLGCMerckWatersCharles River

Posters:

  • An Immunoaffinity-HRAMS Assay for the Pre-Clinical Quantification of Trastuzumab in Rat Plasma
  • Robust and Sensitive Workflow for Qualitative and Quantitative Analysis of Intact Monoclonal Antibodies Using a MicroLC and TripleTOF Mass Spectrometry
  • Improved sensitivity for LC-MS quantitation of biologics in plasma using Trap-and-Elute MicroLC-MS
  • Using Electrokinetic injection to increase throughput and improve sensitivity in the detection of basic Neuropeptides by CESI-MS in biological samples
  • Can CESI-MS improve detection of intact proteins in biological samples?

Booth:

Join us at booth #36 and at our poster presentations to see how SCIEX can help you approach therapeutic quantitation in more innovative and productive ways.

Our drug development services team are presenting and exhibiting at EBF Open Symposium.
Meet our experts on stand: C1

Presentations

Approaches to improve the ADA drug tolerance of Monoclonal Antibody Therapeutic 
Issa Jyamubandi, Scientist, Bioanalytical Sciences, Drug Development Services, LGC

Optimising recovery from volumetric absorptive microsampling (VAMS) devices, to overcome the hematocrit issue for dried samples
Richard Lucey, Scientist, Bioanalytical Sciences, Drug Development Services, LGC

Posters

Improving Robustness and Efficiency in Bioanalysis using “Trap & Back Elute” two dimensional LC-MS/MS
Mike Wright, Principal Scientist, Bioanalytical Sciences, Drug Development Services, LGC

Challenges faced with immunoassay transfers and suggested solutions

Rebecca O’Donnell, Scientist, Bioanalytical Sciences, Drug Development Services

How to Measure Analyte Interconversion

Catarina Horro Pita, Principal Scientist, Bioanalytical Sciences, Drug Development Services

Application of differential ion mobility to boost sensitivity in protein digest LC-MS/MS workflows Rob Wheller, Principal Scientist, Bioanalytical Sciences, Drug Development Services, LGC

This Open Symposium has become a landmark for bioanalytical discussions in EU and has created a true Forum-like spirit where people meet and open discussions during sessions and presentations contribute to the development of an open mind in bioanalysis.

Poster: Biocompatible Solid Phase Micro Extraction (BioSPME): A Tool to Overcome Matrix Effect for Multi-Class Compound Methods

Poster: Evaluation of Recombinant, Chemically Treated Trypsin in Proteomics and Protein Characterization Assays

Poster: Development of Native and Denaturing LC-MS Methods for Characterization of Cysteine-Linked Antibody Drug Conjugates Using a Non-Toxic Mimic

  Join us at our booth during the 10th EBF Open Meeting “A New Journey Begins” and participate to live informatics, service and applications demonstrations aligned with the special themes of the conference.

In addition, we are happy to invite you to 2 extra opportunities to network with your peers:

Waters Exclusive Mini-Symposium]
Tuesday, 14 November 2017 (EBF Opening Night) start at 17:30 – Hotel NH Clollection Barcelona (Hesperia Tower), Auditorium Foyer

Challenges and Opportunities in Large Molecule Bioanalysis

Rainer Bischoff, University of Groningen, 30 mins

[Bioanalysis Zone Fiesta] during EBF Open Meeting 2017
Thursday, 16 November 2017 start at 20:00 – The Dome, Hotel NH Clollection Barcelona (Hesperia Tower)

You are cordially invited to attend an evening to celebrate Bioanalysis. We will enjoy dinner with cocktails, dance and a lot of fun. Access to the Fiesta is very limited.

And also don’t miss…
[Waters Scientific Presentations]
Thursday, 16 November 2017 08:50 – 09:10

Protein Biotherapeutic Quantification: A Comparison of LC-MS Techniques for both Digested and Intact Quantification; John Gebler, Waters