eBook: Bioanalysis of antibody drug conjugates by LC/MS: challenges and solutions

Antibody-drug conjugates (ADCs) are novel therapeutic products that combat cancer by identifying overexpressed antigens on cancer cells, releasing anticancer drugs and selectively killing tumor cells - all without affecting other cells. This is made possible by the toxic drug molecules linked on the monoclonal antibody (mAb) within ADCs, via cleavable or non-cleavable linkers. Thus, ADCs have become highly promising therapeutic products for cancer treatment, particularly after the success of several ADC products being approved by the FDA. However, the complicated nature of ADCs makes bioanalysis challenging to execute. In this eBook, we will explore the various way LC-MS is utilized...