Direct analysis of DBS: emerging and desirable technologies

“...the latest research has shown that direct elution is compatible with whole spot elution without loss of sensitivity or chromatographic performance.” Anyone with an interest in following current trends in bioanalysis over the last few years will have noticed the growing interest in dried blood spots (DBS) and subsequently, dried matrix spots (DMS). It is not difficult to understand the reasons for the widespread, contemporary interest in the foregoing topics. The use of DBS offers numerous advantages over the traditional wet plasma sampling techniques that have been used in quantitative bioanalysis for many years to support drug–development studies [1–4]. DBS...