Development of two complementary LC–HRMS methods for analyzing sotatercept in dried blood spots for doping controls
Analysis of urine with a positive result on doping, the lab technician makes a mark in pencil.
The current routine sampling of blood specimens in sports drug testing faces major challenges ranging from temperature-controlled shipment and storage, limited stability and timely analysis [1] to the need of a phlebotomist for venous blood on-the-spot sampling. To overcome these limitations and increase the number of collected blood samples, the Word Anti-Doping Agency (WADA) pays particular attention to the use of alternative matrices such as dried blood spots (DBS) [2]. This straightforward alternative matrix uses a minimal volume (10–20 μl) of capillary blood collected by a finger, heel or ear prick on a cellulose paper and allows high-throughput and automation of...
