Development and validation of a high performance liquid chromatography–MS/MS method for determination of SOMCL-15-290 in a first-in-human study

Wuhttps X, Zhang F, Liu A, Yu M, Wanghttps H | Bioanalysis, 14(10), 715-724, (2022) Keywords: • cancer • HPLC-MS/MS • pharmacokinetics • SOMCL-15-290 Background: SOMCL-15-290 is a novel inhibitor that targets FGF receptor, CSF1 receptor and VEGF receptor (kinase insert domain receptor). Aim: This study was aiming at developing a specific high performance liquid chromatography–MS/MS method for quantifying SOMCL-15-290 in human plasma and supporting the first-in-human study. Methods: Plasma samples were prepared using the protein precipitation method and separated on a C18 110A column with acetonitrile and 0.2% formic acid solution as mobile phases. Quantification of SOMCL-15-290 was operated...